
When using the M-Audio Oxygen Pro 25 to control Omnisphere, the knobs and buttons on the Oxygen Pro 25 are assigned to the following Omnisphere parameters:
- Knob 1 (cc44) – Global Controls Cutoff
- Knob 2 (cc45) – Global Controls Resonance
- Knob 3 (cc46) – Global Controls Filter Envelope Amount
- Knob 4 (cc47) – Global Controls Vibrato Depth
- Knob 5 (cc62) – Global Controls Ambience Amount
- Knob 6 (cc63) – Global Controls Ambience Length
- Knob 7 (cc75) – Global Controls Unison
- Knob 8 (cc76) – Global Controls Glide
- Bottom [ > ] Button (cc108) – Browser Down / Next Patch
- Top [ > ] Button (cc107) – Browser Up / Previous Patch
Setup
To control Omnisphere using the Oxygen Pro 25, you’ll need to do the following:
- Connect the Oxygen Pro 25 to your computer via USB.
- Set up the Oxygen Pro 25 to control Omnisphere.
- Enable the Oxygen Pro 25 as a MIDI input device in the host software you’re using (DAW, Standalone, etc.).
- Activate the Oxygen Pro 25 Hardware Profile in Omnisphere 3 or later.
OXYGEN PRO 25 SETUP
Omnisphere relies on the factory default settings of Preset 16 while in Preset Mode on the Oxygen Pro 25 for external control.
- Activate Preset mode by pressing the [DAW/ PRESET] button until the [DAW/ PRESET] button is dark / dimmed – this indicates that the Oxygen 25 is in Preset mode.
- Lastly, activate Preset 16 by using the scroll encoder to scroll through the various presets until you see Preset 16 displayed.
HOST CONNECTION
- Open your host (DAW, Standalone, etc.) and make sure the Oxygen Pro 25 is enabled as a MIDI input device.
OMNISPHERE SETUP
- Open Omnisphere and from the header, select the HW menu button.
- From the drop-down menu, select “M-Audio > M-Audio Oxygen Pro 25” to activate the Oxygen Pro 25 hardware profile.

TROUBLESHOOTING
Not working? Here are some things to try:
- Is your DAW receiving MIDI from the Oxygen Pro 25?
- Make sure your DAW is configured to correctly route the MIDI output of the Oxygen Pro 25 to the MIDI channel assigned to the desired part in Omnisphere.
- If you are using the Omnisphere standalone host, make sure the MIDI output channel of the Oxygen Pro 25 matches the MIDI channel of the Omnisphere Part you want to control.
- Are the knobs on the Oxygen Pro 25 sending the correct MIDI CC messages? A simple way to check this is by using MIDI Monitor by Snoize or go into Edit mode on the Oxygen Pro 25 by holding [SHIFT] and press the [DAW/ PRESET] button and then checking the MIDI CC assignments for each knob. See the list above for the correct MIDI CC#s.
SUPPORT
Still not working? More questions?
Feel free to contact us directly and we can work with you:
Tech Support
888-870-4223 toll free
818-955-8444
Monday – Friday 10AM – 5PM Pacific Time
email: info@spectrasonics.net



